Quaternary structure model of cytochrome c oxidase from Drosophila simulans based on homology to bovine (PDB 1v54). Protein subunit COI is colored pink, COII is yellow, COIII is brown, COX4 (isoform 1 of 2, CG106644) is light orange, COX5A (CG14724) is salmon, COX5B (isoform 1 of 2, CG11015) is light blue, COX6A (isoform 1 of 3, CG17280) is yellow-orange, COX6B (CG14235) is sky-blue, COX6C (cyclope) is raspberry, COX7A (CG18193) is pea green, COX7C (CG2249) is slate, and COX8 (CG7181) is sand colored. Blue denotes fixed changes in siI, green fixed changes in siII and red denotes polymorphisms within D. simulans. There are no fixed amino acid changes in siIII. A. Full dimer model of mitochondrial and nuclear encoded cytochrome c oxidase. B. MtDNA subunits shown as a monomer. C. COII subunit only showing the three fixed differences among the distinct mtDNA lineages. The siI mtDNA lineage has one fixed amino acid replacement (Ser 114) while siII has two fixed amino acid replacements (Ile 130 and 165).

The links to the primers used to obtain the data can be found here.

Images of COX subunit models:
COX subunits were modeled by homology using the Swiss-Model workspace

Images were created with PyMol software

PSE file can be downloaded here as a zip file and can be viewed with PyMol or with DeepView. The PDB files are available from w.ballard@unsw.edu.au.